![]() ![]() note Newbies to art/experimental films may walk out of the movie theater in annoyance after sitting through 45 minutes of focusing on some Norwegian guy's expressions (or other Scandinavian nationality or German) as he washes his clothes or takes a bus to work.įor the My Little Pony: Friendship Is Magic blog and webcomic, as well as the episode, click here and here. The art/experimental films would rather show the slow-moving textures and interactions of everyday life in a meditative fashion. Kitchen Sink Drama uses the "slice of life" approach to show a typical day in a working-class character's life: getting up early in a grungy little apartment, working all day at a factory, and coming home to make an inexpensive dinner, all while dealing with the trials and tribulations of being in a lower income category (unemployment, living paycheck-to-paycheck, depression, etc).Īrt films and indie/experimental films also often use the "slice of life" approach, as these films tend to have a looser, more open-ended structure and they are not goal-directed like Hollywood blockbusters (where the hero is always chasing a MacGuffin or trying to achieve a Plot Coupon). In some ways, Slice of Life overlaps with stories generally considered Lit Fic in the west, since both genres cover ordinary human lives, motivations, and emotions, though Slice of Life doesn't always imply the stereotype of intellectual snobbery or elitism that surrounds works of Lit Fic, as well as the impression that Lit Fic somehow has to be "depressing" or have Downer Endings. Since the casts of such shows tend to be mostly if not entirely female, English-speaking fans sometimes refer to them as "cute girls doing cute things". See also Iyashikei, which often overlaps with this trope. See Schoolgirl Series for a specific type of Slice of Life. This often gets combined with a Mood Whiplash when the pace of the action picks up. In longer-running action-based shows it is also becoming fairly common to incorporate Slice of Life episodes to flesh out the characters by placing them in a more mundane setting. Surprisingly popular in Japan, so a lot of Anime fills this category. For a complete index, see Slice-of-Life Webcomics. Not to be confused with the Journal Comic, although they may overlap. Several Webcomics are Slice of Life, while the ones labeled " Real Life" are usually not real life at all, but tend to fall into some brand of Speculative Fiction, or at the least Life Embellished. When it is, the TV industry in particular calls it "low concept" (in contrast to High Concept). Slice of life also doesn't have to be set in the world as we know it. Most American newspaper comics that aren't simply gag a day strips are stories like this due to the simple fact that most people do not read newspapers every day and archives of comic strips are rare, so they need to be able to jump into the comic's world at any time and be able to appreciate it. An example of this would be how in many slice of life school stories, parents are nearly non-existent. Slice of Life series don't usually have much of a plot or, if taken to extreme, even the omnipresent Conflict, but they don't really need one, and many Slice of Life stories use a lack of conflict to serve peaceful escapism rather than realism. For example, a story about hilarious roommate hi-jinx may depict the mundane life of roommates, but these mundane events are usually the setups and punchlines of jokes or part of the conflict between the characters, which takes away their slice-of-life-ness and cements them firmly in the realm of comedy or drama. What separates slice of life as a genre from the literal meaning of the phrase (which would encompass nearly all fiction) is the emphasis on the very moment, with the intent of focusing the audience on that moment rather than using that moment as part of a narrative. Coming of age is often a major part of their stories. School is perhaps the most common setting for these kinds of series, especially in animation. A cast of characters go about their daily lives, making observations and being themselves.
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![]() ![]() And if r/storyofseasons is anything to go by, plenty of people are happy with small tweaks to the farming as long as there's a new (or looking at the reaction to the remake, at least beloved) cast of husbandos and waifus. If anything, the reactions to the recent Story of Seasons seem to criticize what was changed from Trio of Towns, rather than what was kept the same. Most games have some "gimmick" mechanically that doesn't carry on to the next, but are still easy to pick up and play if you're familiar with the series. YMMV, but I think Story of Seasons generally does a good job of changing up mechanics each release. Whether or not that makes the next game "stale" is going to be a matter of opinion. For Story of Seasons that usually means new-but-archetypical characters, a variant on the "restore the farm" story, and a nebulously premodern setting. That can be setting and mechanics, theme, story, characters, or any number of things. Generally (though not always) a game that's part of a series will have strong similarities to other games in the series. /r/GamePhysics - Clips of game physics shining and glitchingĭesign based on /r/FlatBlue created by /u/creesch./r/gaming4gamers - middle ground between purely-for-fun and more serious subreddits./r/GamingLeaksAndRumours - Leaks and Rumors.Posting unmarked spoilers will result in removal and warning, and posting spoilers with malicious intent will result in a ban. Please report posts containing spoilers unless they are hidden using the following method or are inside a thread clearly labeled as containing spoilers. If you want to promote without participating in the community, purchase an ad. For more information, see the self-promotion on reddit FAQ. Some promotional submitting (posting your own projects, articles, etc.) is permitted, but it must be balanced out by a much greater level of non-promotion participation in reddit - the rule of thumb is no more than 10% of your submissions may be promotional. Promotion must be kept within acceptable limits.Follow all specific content restrictions.No off-topic or low-effort content or comments. ![]() No personal attacks, witch hunts, bigotry, or inflammatory language.No content primarily for humor or entertainment.Questions likely to generate discussion.Shadow Gambit: The Cursed Crew Mimimi Games Want to schedule an AMA with us? Read our guidelines for more information! To see previous AMAs, click here. ![]() New to reddit? Click here! Subreddit Calendar Submissions should be for the purpose of informing or initiating a discussion, not just with the goal of entertaining viewers.įor examples of quality discussion posts we'd like to see in our subreddit, please review this page.įor an in-depth explanation of our rules, please review our rules page. The goal of /r/Games is to provide a place for informative and interesting gaming content and discussions. If you're looking for "lighter" gaming-related entertainment, try /r/gaming! Please look over our rules and FAQ before posting. Software description provided by the publisher./r/Games is for informative and interesting gaming content and discussions. The music is closely entwined with the narrative and features a music score created with the help of a real orchestra, that responds to your choices. From the local butcher Kim (they/them), to Amira (she/her), a flirty doctor.ĭevelop both domestic and magical crafts through cooking, fishing, farming, animal care, magical spells and potions.Įxplore and relax through 35-60+ hours of immersive gameplay. Seven folks of Fairhaven are eligible to be wooed and romanced. The characters in Wylde Flowers are brought to life with a cast including BAFTA award winning voice actors in over 18 hours of voice acting.įrom Natalia (she/her) the local Blacksmith, to Sophia (she/her) who runs the diner, each character in Fairhaven has an intricate backstory waiting for you to love and fall in love with. Savor an earnest and emotional story that blends farming with magic and personal discovery as Tara finds herself, and brings a town together. By night, nurture your inner witch as you learn to fly your broomstick, brew potions, control the weather and seasons or even transform into a cat! Relax into your rural lifestyle as you tend crops, care for animals, fish, craft, and more throughout the day. Get to know a memorable cast of fully voiced characters with intriguing backstories - find friendship or even romance! Play as Tara (she/her), who has just moved to a cute rural island to help out her grandma and the family farm. ![]() The multiplication and division worksheets grade 3 is designed for third-grade students to practice and reinforce their understanding of multiplication and division concepts. Thus, free printable counting money worksheets 3rd grade are a great way to help students understand this basic Get worksheet Multiplication and Division Worksheets Grade 3 For little kids in third grade, it is fundamental to fathom and use the idea of money. Money is a part of our daily lives, so knowing its value and how to use it well is essential. Students Get worksheet Counting Money Worksheets 3rd Grade ![]() About Counting Quarters Worksheets A counting quarters worksheet free allows students to practice adding and subtracting quarters. Counting quarters worksheets are an excellent way to develop this ability. In addition to assisting with fundamental math concepts, it provides a foundation for financial literacy. What Are Nickel Counting Worksheets? The counting nickels worksheet PDF Get worksheet Counting Quarters WorksheetsĬounting quarters is an essential skill for young learners to acquire. ![]() One method for supporting this expertise is using counting nickels worksheets. It is a fundamental skill that will help students get a strong sense of number sense and comprehend the fundamental concepts of addition and subtraction. Math for Kids Is Your Child Struggling With Math?ġ:1 Online Math Tutoring Let’s start learning Math! Counting Nickels WorksheetsĬounting nickels is a significant expertise that kids acquire. Multiplication and division facts worksheets Get worksheet Using fact families multiplication and division worksheets, you can easily teach them how to work with this math concept. Children should know how to solve addition, subtraction, and each equation around the fact families. There are fact families in multiplication and division which your kids must learn to work with. Multiplication fact worksheets visually represent all the multiplication Get worksheet Multiplication and Division Fact Families Worksheets Kids must learn the basics of multiplication when they are younger they should understand word problems, multiple-choice questions, and other types of tasks within the multiplication universe. It is the foundation for solving numerous complex world-problem-solving equations we encounter today. Multiplication is an essential aspect of math. Therefore, kids need the Get worksheet Multiplication Facts Worksheets Moreover, they only need to memorize more significant division problems that will be needed to solve derivatives. However, with division facts, kids only need to remember them instead of learning how to solve them. "synopsis" may belong to another edition of this title.When it comes to division, kids soon realize it is a more complex idea than they envisage. Today, Teacher Created Materials and Shell Education are two of the most recognized names in educational publishing around the world. The story continued in 2004 with the launch of Shell Education and the introduction of professional resources and classroom application books designed to support Teacher Created Materials curriculum resources. What began as a hobby, selling lesson plans to local stores, became a part-time job after a full day of teaching, and eventually blossomed into Teacher Created Materials. Both were eager to share their ideas and passion for education with other classroom leaders. ![]() Rachelle Cracchiolo started the company with a friend and fellow teacher. Encourage your Third grade students to approach math with confidence, not fear, with daily practice! The 180 Days of Math workbook includes data-driven assessment tips and digital resources for parents and teachers, making diagnostics easy. The daily activities are great as homework or as additional reinforcement of math concepts outside of class. With educational activities that are correlated to College and Career Readiness and other state standards, 180 Days of Math helps to prepare students for the future. Students will practice addition, subtraction, multiplication, and division, as well as tackling algebraic thinking, data analysis, logic problems, and more. 180 Days of Math for Third graders provides workbook problems for each day of the school year, giving students ample time to use the skills they learn in class.Įach problem is tied to a specific mathematical concept, allowing students to master skills and prepare for the next level of learning. Consistent practice is the best way for students to develop math skills and confidence, at any grade level. ![]() The SP360 weighs only 3.63 ounces (103g) and is sold with 3 different accessory bundles so users can take the action cam on the go depending on their activity or adventures. The SP360 Action Cam comes with: a rechargeable Li-ion battery, battery charger, AC adapter, Micro USB cable, clear plastic lens cover, protective lens cover, carrying case and cleaning cloth. It is compatible with a microSDHC memory card, Class 6 or higher and up to 32GB capacity (memory card sold separately). ![]() ![]() The KODAK PIXPRO SP360 Action Cam is splash proof, freezeproof (-10 degrees c), shockproof (2m), and dustproof. The SP360 uses the free PIXPRO SP360 iOS or Android-based App available in Apple's iTunes and Google Play stores now. The SP360 Action Cam is Wi-Fi® enabled and allows quick connection to a smart phone, smart device or personal computer (iOS™ 6, Android™ 4.0, Mac™ OS X10.9, or Windows™ 8/7 systems or higher) to act as an additional method of remote control or for viewing the content the user is shooting from up to 65 feet away. Users can also select individual frames from different viewing perspectives in the HD video and save them as hi-resolution still photos for even more creative ways to capture and share their passions and experiences.įor even more flexibility, the SP360 is equipped with a motion sensor setting to automatically trigger recording when it detects movement, especially helpful for hands-free activities. Once the HD video is downloaded from the SP360 to a computer, users have the ability to pan and select a multitude of viewing angles (including: top, left and right) and save them as new video files. The SP360 Action Cam goes beyond just capturing fully immersive 360 degrees HD video and adds a new level of interactivity with free, de-warping app software included for Mac or PC based systems, that allows owners to edit their content post capture. "The SP360 Action Cam revolutionizes this sometimes cumbersome process and streamlines what really matters, capturing users not only doing what they love, but them engulfed in doing it," said Mike Hackett, executive vice president of JK Imaging, Ltd. Until now, 360 degrees panoramic photography required most users to possess some advanced techniques, specialized equipment, editing software to stitch content together and most importantly, the need for multiple cameras. The SP360 Action Cam is small enough to fit in the palm of your hand and sports a unique, dome-shaped fixed lens that captures stunning 360 degrees HD videos (30fps) that can be shot and viewed from multiple vantage points including: 360 degrees Panorama, Front (212 degrees), Split with 180 degrees front and rear views simultaneously, Dome (214 degrees) and Ring/Sphere (360 degrees) modes. This game-changing, innovative and highly portable device is designed to capture stunning 360 degrees HD videos and fully immersive images all in one shot and without the need for multiple cameras and devices. 28, 2014 - JK Imaging, Ltd., the worldwide licensee for KODAK PIXPRO Digital Cameras and Devices, announced today its new SP360 Action Cam. Press release: New Kodak PIXPRO SP360 Action Cam Redefines 360 Degrees HD Video And Panoramic Photography With A Single, Compact And Personal Device The Kodak PixPro SP360 is available now for around $349. The SP360 is also quite small and light, weighing in at only 103g/3.63 oz. The unit supports the use of MicroSD and MicroSDHC cards up to 32GB, and the internal battery provides approximately 350 shots or 160 minutes of 1080p video. Five viewing modes are available including 360 degrees Panorama, Front (212 degrees), Split with 180 degrees front and rear views simultaneously, Dome (214 degrees) and Ring/Sphere (360 degrees). Users can user built-in Wi-Fi to control shooting via the PixPro Remote Viewer app for Android and iOS, with NFC available for easier pairing. The camera itself is designed to survive drops of 2 meters, along with temperatures as low as -10☌/14☏, and is also dustproof and water resistant. The unit can also capture 10MP JPEGs at up to 10fps in burst shooting mode. The SP360 uses a 16 megapixel CMOS sensor (though offers 1:1 10MP stills as its highest resolution output) for recording MP4 1080p video at 30fps or 720p video at 60fps. The SP360 offers an extreme 360 degree viewing range thanks to its ultra-wide F2.8 lens, and is able to capture full HD video footage along with 10MP stills. Kodak licensee JK Imaging has recently introduced the PixPro SP360 action camera to its lineup of active photo equipment. ![]() As a beginner, your first step is to familiarize yourself with various Mobile Suits. Just try everything you have – experiment with different suits, their abilities and how they align with the way you play. This means as a beginner, you should focus on getting a feel for different mobile suits and see which one clicks with you. On many occasions, what works best for a player can be different from what’s considered “top tier”. Unlike other games, in GBO2 there is a strong emphasis on personal skill and playstyle over any predefined tier list. Learn the categories of Mobile Suits Ignore Tier Lists You can also customize the suit’s weaponry and colors. ![]() Your suit also has a level and cost which changes based on its performance. They follow a rock-paper-scissors type of deal, where each class is strong against one and weak against the other. The game has 3 classes for mobile suits: raid, general, and support. ![]() Supply drops can give you mobile suits or weapons. Each game has different names for this system. You play the game, earn some in-game currency, and use it to randomly get items. GBO2 uses this thing called a gacha system, sort of like those old toy vending machines. So that your journey from a rookie to an accomplished player stays smooth and enjoyable. This guide serves to demystify the world of GBO2 for beginners with clear directions on what to do and what to avoid. Yet, the vast range of over 350 Mobile Suits, coupled with the sheer number of tier lists, can be intimidating for those just dipping their toes in the game. For beginners, tier lists can be an invaluable tool to get started. As Mobile Suit Gundam: Battle Operation 2 debuts on PC, it’s set to attract a wave of newcomers. Harmless Boogie by The Pearly Shells feat. The Solution Is Restless (2021) - Joan As Police Woman x Tony Allen x Dave Okumu by Joan As Police Woman Tony Allen Dave Okumu Joan As Police Woman x Tony Allen x Dave Okumu - 'The Barbarian' Not a PBS member? Sign up now for your chance to win. Tune into PBS all week for your chance to win a copy of the album. Remember the Future? is out now via Marthouse Records. Having drawn comparisons to Parquet Courts, Tropical Fuck Storm and Devo, Dr Sure's Unusual Practice is one to watch. Remember the Future? was recorded over two days (with a year and a global pandemic in between), with studio wizards Nao Anzai (Rolling Blackouts C.F, Floodlights) and Max Ducker (Amyl & The Sniffers) The Beach Boys: Summer Favorites & Beach Music Classics1-4 (5 CD Set). I’m trying to make some sense out of it, or at least document it.” reacting to whatever’s dominating the news feed, it’s all catastrophes and conspiracies. On the lyrical content of the album, lead songwriter, vocalist and guitarist, Dougal Shaw said: ". found himself on the scene when some of the most pivotal moments in glam. Their latest release delivers ten robo-punk anthems which document the absurd times we've all found ourselves in. The CD's songs, all penned by Hoffman (with the exception of 'I Can't Remember. and his current ascendance is, among other things, merely a moment in a long career. This week's Feature Album comes from Melbourne new-wave art-punks Dr Sure's Unusual Practice with their new album Remember the Future?.ĭr Sure's Unusual Practice emerged from the Melbourne underground in 2019 with their debut release The West, followed by 2020's fiery EPs Scomo Goes to Hawaii and While Aus Burns. 1 album and single, 1 972's Harvest and its 'Heart of Gold. Patti Page and Nick Clooney co-host new performances and archival classics from the vault featuring the Four Lads, Four Aces, Four Freshmen, Roger Williams. ![]() It left you to think about things in just the right places. ![]() The plot itself is clear and concise but it didn’t reveal everything about the world. ![]() They’ll be stories about a great battle, victories and defeats, and other details that gradually build up the lore. In addition, some enemies will provide even more backstory as your skulking about. In order to free her you have to travel the Japanese inspired world and collect artifacts that will unlock her prison. She can essentially project herself so she’s by your side and teaches you the mechanics of the game, adds exposition to the story, delivers commentary about the world around you, and basically acts as a non-corporeal companion. You’ve been called upon to rescue a lady from her captors named Yamiko, who is the one responsible for your resurrection. The story starts off with you controlling a summoned and revived spirit, or an Aragami. If you aren’t sold yet, continue reading on for the full review. Plus, it’s developed by an indie studio (Lince Works) which makes this even more impressive. The gameplay, the story, the visuals, and the sound are so nicely wrapped up in charm that I scold myself for not being more excited about this title. I’m more or less three playthroughs in and still going back to it so I can complete the game one hundred percent. ![]() Iori and Kyo navigate the beginning of their relationship during the KOFXV tournament.Aragami surprised me in many ways as I wasn’t expecting a stealth game to have such depth. Language: English Words: 108,026 Chapters: 29/30 Comments: 4 Kudos: 30 Bookmarks: 5 Hits: 1,218 What she gets instead is a job offer, Geese’s attention, and a look into the underbelly of power. Not wanting to be indebted to him, she seeks to find out why. Graphic Depictions Of Violence, Major Character Death, Rape/Non-ConĪ night in jail takes a turn for the unexpected when Mai is bailed out by Geese Howard.LordiTheUltimate Fandoms: King of Fighters Has Chris already gone too far? Yes! But will this be Total Drama? Also yes! Find out what the drama is about in the biggest season ever. With dangerous old and new challenges mixed, more drama, friendship and romance than can be carried by hand and strategies that come straight out of nowhere, this is the ultimate season in every way. Some of them may be old and the rest of are new, but the competitive, dramatic and game-playing spirit is in all of them. Which is why he pitted 120 (and something) contestants against each other from many, many worlds on a whole bunch of islands. Il Conduttore del Carro | The Coachman (Pinocchio)Ĭhris is back, has opened inter-dimensional doors after two apparent comeback seasons and clearly isn't insane.Thenewsubwayguy Fandoms: Total Drama (Cartoon) Language: English Words: 60,536 Chapters: 56/? Comments: 43 Kudos: 72 Bookmarks: 20 Hits: 28,942 What follows is a series of crossover pairings that interested me in my own mind, may not make sense, but it is hot. Ultradeth Fandoms: Final Fantasy X, Queen's Blade, Street Fighter, Tomb Raider (Video Games), Gravity Falls, Bleach, Danny Phantom, Final Fantasy VII (Video Game 1997), 超重神グラヴィオン | Gravion (Anime), Kochikame: Tokyo Beat Cops, Spyro the Dragon (Video Games), The Loud House (Cartoon), Duncanville (Cartoon), Grand Theft Auto: Vice City, Legend of Queen Opala (Video Games), Big City Greens (Cartoon), Dead or Alive (Video Games), Fairly OddParents, Rick and Morty, Rugrats & All Grown Up! (Cartoons), King of Fighters, A Plague Tale: Innocence (Video Game), Soul Calibur, Biohazard | Resident Evil (Gameverse), Overwatch (Video Game), One Piece, Stripperella (Cartoon), Amphibia (Cartoon), The Owl House (Cartoon) Language: English Words: 17,262 Chapters: 8/? Kudos: 2 Hits: 88 But they screwed up royally and had to turn to plan B, conning Chizuru and Krauser into organizing a new King of Fighters tournament in order to lure the vessel for Ambrosia and finish him off once and for all. Some time ago the Holy Warriors from an ancient prophecy gathered to stop Amakusa from reincarnating in our times. Creator Chose Not To Use Archive Warnings.Shoganeena Fandoms: King of Fighters, Fatal Fury, Ryuuko no Ken | Art of Fighting (Video Games), Samurai Spirits | Samurai Shodown (Video Games) KOF MAXIMUM ULTIMATE MATCH SPECIAL PREMIUM ![]() All information is deemed reliable but not guaranteed. Listing information provided in part by the North Texas Real Estate Information Systems, Inc, for personal, non-commercial use by viewers of this site and may not be reproduced or redistributed. This property listing is offered without respect to any protected classes in accordance with the law. and ZeroDown assume no responsibility for typographical errors, misprints or misinformation. Houston Realtors Information Service, Inc. The information on each listing is furnished by the owner and deemed reliable to the best of his/her knowledge, but should be verified by the purchaser. The information included in this listing is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. Houston Realtors Information Service, Inc., ZeroDown and their affiliates provide the MLS and all content therein “AS IS” and without any warranty, express or implied. All information provided is deemed reliable but is not guaranteed and should be independently verified. © 2023 Houston Realtors Information Service, Inc. Information deemed reliable but is not guaranteed accurate by ACTRIS. ![]() Real estate listings held by brokerage firms other than this site owner are marked with the IDX/MLS logo. Any information relating to real estate for sale referenced on this web site comes from the Internet Data Exchange (IDX) program of the ACTRIS. The information being provided by ACTRIS is for the consumer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumer may be interested in purchasing. Columbia 24" Single Vanity Cabinet, Latte Oak, Matte Black. James Martin Furniture is an industry leader in premium-quality bathroom vanities designed from the ground up to transform bathroom spaces from mundane to remarkable. The Metropolitan 48" American Walnut single vanity by James Martin Vanities is a wall-mount optional cabinet with mounting brackets and chrome finish legs, offers ample storage space, soft-close doors and drawers. Bring the simplicity of design to your bath with the fully modular collection by James Martin … James Martin Vanities is a leading manufacturer of bathroom vanity cabinets. Addison 72" Double Vanity Cabinet, Mid Century Acacia. 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Enjoy our superb selection and work with the helpful experts at … by James Martin Furniture. Brookfield 60-in Antique Black Undermount Double Sink Bathroom Vanity with Carrara White Marble Top. ![]() The research concludes that Dan Zhu’s ideas fit well with Xuan-zong’s (唐玄宗) appeal for revival of Confucius teachings and the social-political setting in Mid-Tang. Coupling with the civil examination (科舉) reform and the impacts of Zen Buddhism, the Tang society was undergoing major social-political transformation which Dan Zhu was situated right on its course. Tang imperials whose ancestors carried a nomadic blood stream tried to strengthen their control by adopting Confucianism and placing more emphasis on the south-eastern region where the Han Chinese of the Southern Dynasty was concentrated. From Dan Zhu’s perspective, Confucius was trying to make use of histories to set proper behavioural standards and protocols for running the country, with an objective of saving the imperial control of Zhou (周).ĭuring the mid-Tang period, China was undergoing major social changes from a feudal to a modern society. Moreover, the Tang scholars are treating Chun Qiu as history or even as literature, rather than Confucius’ teaching on how the society should be run. He considers that there are large amount of mistakes in the then contemporary explanation of Chun Qiu, he also considers that Tang scholars have not just worked in isolation without much view sharing, but also misinterpreted Confucius’ teachings. ![]() This research reveals that Dan Zhu abandons the approach of focusing on the meaning wording and goes directly into the teachings of the classics. Nevertheless, due to the controversial nature of his teachings, Dan Zhu was heavily criticized by Ouyang Xiu (歐陽修) as being specious and at the same time appraised by Cheng Yi (程頤) to be one of the fore-runners who founded the Song Confucianism. This has made Dan Zhu even more influential than other Confucius scholars in that period. Many famous Tang political reformers including Lu Wen (呂溫) and Liu Zong Yuan (柳宗元) are considered by historians as Dan Zhu’s students and followers. To avoid the An-Shi Rebellion, Dan Zhu resided in the south-eastern part of the country where he taught Lu Chun (陸淳) the Chun Qiu (春秋) classic. Among the various scholars during the course of this transformation, Dan Zhu (啖助,724-770) has been recognized as a non-mainstream but yet very influential character. The intellectual development in the Tang Dynasty (618-907) could be generally divided into two phases, with the first one inherited from the Han Wei period focusing on the meaning of words, while the second phase focuses on the teaching of the Confucian classics. Philadelphia (PA): AACR Cancer Res 2022 82(12_Suppl):Abstract nr 5091. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022 2022 Apr 8-13. The early change of serum interleukin 14α levels predicts the response to anti-PD-1 therapy in cancer. Keywords: IL14α, serum biomarker, anti-PD-1 therapy response, cancer Citation Format: Bu Hai Wang, Cai Yue Chen, Xian Zhang, Yu Xiang Huang, Yi Chun Zeng, Lei Li, Mao Qi Wang, Jing Liang Guo, Qiu Xian Li, Long Shen, Juan J. Conclusion: Early changes of serum IL14α level may be a useful predicting factor in advanced cancer patients with anti-PD-1 therapy. Using this cutoff to subgroup the patients, we found higher delta IL14α % change was significantly associated with superior overall response to anit-PD-1 therapy (p=0.0072) and had a better progression free survival (p=0.0039). Receiver operating characteristic (ROC) was analyzed to get a cutoff point of delta IL14α % change as 2.46% (Sensitivity 85.71%, Specificity 62.5% AUC=0.7277, P=0.034). Early change of IL14α after 2-cycles of anti-PD-1 therapy was calculated as delta IL14α % change = (IL14α level after 2 cycles - IL14α level before treatment)/IL14α level before treatment*100%. There were no association between the expression levels of IL14α and clinical outcome. Result: Among these 30 patients, the mean expression level of IL14α before treatment was 2.1☑.21, whereas the mean level of IL14α after 2 cycles was 1.99☐.82. Serum levels of IL-14α were tested at baseline and after 2 cycles of treatment. Patients and methods: Thirty advanced cancer patients treated with PD-1 inhibitor were enrolled in this study. We evaluated serum interleukin 14α (IL14α) as a biomarker to predict the response of anti- PD-1 therapy. Abstract Background: Targeting programmed cell death-1 (PD-1) or programmed cell death ligand-1 (PD-L1) has been shown improved clinical efficacy in a wide range of tumor types. |
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